The NightLife study - the clinical and cost-effectiveness of thrice-weekly, extended, in-centre nocturnal haemodialysis versus daytime haemodialysis using a mixed methods approach: study protocol for a randomised controlled trial.

Furthermore, the FHN Nocturnal trial demonstrated that allocation to the intervention hastened residual kidney function decline in comparison to the control [ 30 ] and a trend towards increased vascular access events with extended-hours nocturnal haemodialysis [ 28 ], although this did not reach statistical significance and synthesised data from all three trials indicated there was no difference in vascular access events between intervention and control [ 31 ].

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