Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells.

NPJ Vaccines · 2023 · PMC10423246 · PMID 37573434

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 0.001actually significant

There was a strong and highly significant correlation between baseline Spike+RBD+ memory B cell frequency and D614G-specific antibodies in previously infected individuals (R = 0.84; P < 0.001), confirming the expected relationship between these two parameters.

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did not reach statistical significanceno p-value reported

Although this did not reach statistical significance, it suggests that low-frequency spike-cross-reactive B cells exist in individuals who have not been infected with SARS-CoV-2.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.