Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort.

Ann Rheum Dis · 2023 · PMC10423473 · PMID 37258065

Europe PMC DOI

hedged sentences

0.0850

closest p · 1.7× alpha

0.0850

boldest claim

The sentences

a trend towards significancep=0.085so close (0.05 < p ≤ 0.1)

In subgroup analysis with patients who reached clinically relevant reduction on weight (defined >5%), we observed a trend towards significance for the comparison between GLP-1RA and non-GLP-1RA groups (0/135 (0.0%) vs 6/211 (2.8%), p=0.085) ( online supplemental table S16 ).

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did not reach statistical significanceno p-value reported

Nonetheless, the ‘direct effects’ of GLP-1RA on knee surgery, apart from the weight loss-mediated pathway, did not reach statistical significance ( table 3 ).

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