Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats.

Neoplasia · 2023 · PMC10423691 · PMID 37567055

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a decreasing trendno p-value reported

However, after treatment with sitagliptin, there is a decreasing trend in permeability though without significant differences ( Fig. 8 G).

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did not reach statistical significanceno p-value reported

In comparison to the control group, the concentration of active GLP-1 was slightly higher in the diarrhea rats at 0h, but this difference did not reach statistical significance.

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an increasing trendno p-value reported

Similarly, the total GLP-2 concentration showed an increasing trend but without significant differences.

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