Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study.

The causal relationship between gene-simulated inhibition of PCSK9 and HMGCR and autoimmune diseases Genetically predicted inhibition of PCSK9 had an obvious protective effect on SLE in both the IVW method (OR [95%] = 0.47 [0.30 to 0.76], p = 1.74 × 10 −3 ) and weighted median method (OR [95%] = 0.38 [0.21 to 0.68], p = 1.21 × 10 −3 ), while inhibition of HMGCR did not reach statistical significance (IVW: p = 0.46; weighted median: p = 0.39) (Fig. 2 ).

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