Bi-variate analysis identified factors included in a multivariate model showing that factors influencing risk of aGvHD were: mieloablative conditioning (HR 1,56; 95%CI 1.03-2,38; p=0.03), Simpson alfa-diversity <0.90 (HR 1,65; 95%CI 1.08-2.51; p=0.02) and OA (HR 0,59; CI95% 0.36-0,98; p=0.04); type of aGvHD-prophylaxis or donor type did not reach statistical significance.
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P1264: A PREDEFINED STRATEGY AIMED TO REDUCE ANTIBIOTIC EXPOSURE OF SCT RECIPIENTS PRESERVES DIVERSITY AND COMPOSITION OF INTESTINAL MICROBIOTA AND REDUCES THE INCIDENCE OF ACUTE-GVHD WITHOUT SIDE EFFECTS
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