The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis.

The median disease severity score was also lower in Ifngr1 −/− mice than in control mice, although this did not reach statistical significance ( p = 0.12) ( Supplementary Fig. 2A ).

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Likewise, although IFN-γ but not IL-10 induced robust STAT1-dependent induction of Cxcl9 , Cxcl10 , and Cxcl11 , the addition of IL-10 had quite modest which only attained borderline significance for Cxcl9 ( Fig. 7C ).

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