Comment on "Chemoradiotherapy Followed by Active Surveillance Versus Standard Esophagectomy for Esophageal Cancer: A Systemic Review and Individual Patient Data Meta-Analysis".

The lone source of nonretrospective data, a randomized trial published by Park et al, also showed a trend toward improved disease-free survival for patients undergoing esophagectomy opposed to those randomized to observation alone. 4 Ultimately, at the crux of any discussion of active surveillance, is our ability to define and detect a complete clinical response.

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