An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold.

Quantification of the position of E12.5 pulsed cells shows a clear trend for EdU+ cells to locate closer to the pial surface (Bin 1) in Emx1Cre;CasTcKO cortices than in controls where they tend to settle in layer VI ( Fig 4A ; Mann–Whitney U test with Bonferroni correction, * p < 0.005, two-tailed test for Bin 7, n = 5 animals per genotype).

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