Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of <i>Gabrb1</i>^-/- mice.

The results showed that Glu and the ratio of Glu/GABA were increased in Gabrb1 −/− mouse hippocampi ( Figures 5 N–5P), while Gln had an increasing trend ( Figure 5 M).

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We found that Glul (encoding glutamine synthetase), Slc38a3 (encoding sodium-coupled neutral amino acid transporter 3), and Grm3 (encoding glutamate metabotropic receptor 3) were up-regulated, while Slc1a2/3 (encoding excitatory amino acid transporter 2 and 3) showed a trend in upregulation ( Figure 5 G).

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