Echocardiographic evaluation of right heart failure which might be associated with DNA damage response in SU5416-hypoxia induced pulmonary hypertension rat model.

Respir Res · 2023 · PMC10433698 · PMID 37592245

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highly significantno p-value reported

Consistent with Spyropoulos and colleague’s measurements[ 13 ], our results showed that the correlation was highly significant between RVSP and echocardiographic parameters evaluating right heart function (reflected by RV free-wall thickness and PAT/PET).

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an increasing trendno p-value reported

In the SuHx groups, SERCA2 levels displayed an increasing trend in week 1 that was not statistically significant, a significant increase in expression in week 2, a non-statistically significant decline in week 4, and a significant decrease in week 6.

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showed a trendno p-value reported

The expression of SERCA2 in the right ventricles of SuHx-induced PH rats The expression of sarco-endoplasmic reticulum calcium ATPase 2 (SERCA2), a functional protein in myocardial cell, showed a trend of initial increase and followed by subsequent decrease in SuHx-induced PH rats.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.