Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study.

J Headache Pain · 2023 · PMC10439594 · PMID 37596566

Europe PMC DOI

hedged sentence

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closest p · 1.2× alpha

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boldest claim

The sentences

nearly significantp = 0.06so close (0.05 < p ≤ 0.1)

Result The use of genetic proxies for HMGCR inhibition demonstrated a significant association with a decreased risk of migraine in the FinnGen dataset (OR = 0.64, 95% CI: 0.46–0.88, p = 0.0006) and a nearly significant association in the Choquet dataset (OR = 0.78, 95% CI: 0.60–1.01, p = 0.06).

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