Kidney function, albuminuria, and their modification by genetic factors and risk of incident dementia in UK Biobank.

One meta-analysis [ 13 ], which included 8 prospective population-based studies examining the association between eGFR and cognitive impairment or dementia, concluded that the overall association did not reach statistical significance (odds ratio [95% CI] for eGFR < 60 ml/min/1.73m 2 = 1.28 [0.99–1.65]); among the three studies that focused on dementia risk, the largest had 7,839 participants (564 incident dementia cases) [ 40 ], and the longest had a median follow-up duration of 6 years [ 41 ].

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