TDP-43-regulated cryptic RNAs accumulate in Alzheimer's disease brains.

As expected, the discriminatory ability of all five cryptic RNAs was highly significant ( P < 0.0001) in the frontal cortex and amygdala in FTLD-TDP, with AUC ranging 0.79–0.98 in amygdala and 0.81–0.94 in frontal cortex (Fig.

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In our study cohort, we observed that FTLD-TDP type B tended to have lower levels of pTDP-43 burden in the frontal cortex, although it did not reach statistical significance (Fig.

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