We then measured detergent-soluble STMN2 protein in the frontal cortex by Western blot, which revealed a significant or nominally significant reduction of STMN2 protein in all FTLD-TDP cases compared to controls in unadjusted analysis and adjusted analysis when controlling for age and sex, respectively ( Figure 1A ; Supplementary Table S2 ).
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CRISPR interference to evaluate modifiers of <i>C9ORF72</i>-mediated toxicity in FTD.
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