The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5.

The mean infectious titre of BA.5.2 (0.9 × 10 5 PFU/g) in lungs of infected animals was slightly lower than that of BA.1 (1.4 × 10 5 PFU/g) and BA.2 (1.9 × 10 5 PFU/g), but did not reach statistical significance ( Fig. 4 D).

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