From the literature above, we can see that the research on the resistance of SA to MLs first experienced a rapid rising and then showed a decreasing trend of volatility, with certain regional differences in China.
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In conclusion, from 2000 to 2010, the resistance rate of SA to MLs showed a trend of fluctuating increase and then decreasing.
In the past 30 years, the resistance of SP to MLs in children in China has shown an increasing trend, especially in the 1990s, when a sharp upward trend occurred, and then maintained at a high level. ermB and mefA genes are major SP of resistant to MLs.