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Severe problem of macrolides resistance to common pathogens in China.

Front Cell Infect Microbiol · 2023 · PMC10448830 · PMID 37637457

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a decreasing trendno p-value reported
From the literature above, we can see that the research on the resistance of SA to MLs first experienced a rapid rising and then showed a decreasing trend of volatility, with certain regional differences in China.

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showed a trendno p-value reported
In conclusion, from 2000 to 2010, the resistance rate of SA to MLs showed a trend of fluctuating increase and then decreasing.

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an increasing trendno p-value reported
In the past 30 years, the resistance of SP to MLs in children in China has shown an increasing trend, especially in the 1990s, when a sharp upward trend occurred, and then maintained at a high level. ermB and mefA genes are major SP of resistant to MLs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.