Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Therefore, to adjust for multiple testing, we considered a genetic correlation finding study-wide significant in the LDSC analysis at P < 8.26 × 10 –3 (0.05/6.1849) and nominally significant when P < 0.05.

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For instance, the observed proportion of genes overlapping migraine (16.6%) and headache (17%) with FG at P gene ≤ 0.05 was significantly higher [ P binomial-test = 1.24 × 10 –16 (migraine and FG) and P binomial-test = 4.74 × 10 –14 (headache and FG)] than the expected proportion (11.5% for migraine and FG, and 11.4% for headache and FG), providing additional evidence for highly significant genetic overlap between migraine and headache with FG (Supplementary Table S8 (Table II)).

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