Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model.

Compared with our previous study of mice on a folate-sufficient diet, folate-deficiency was associated with a doubling of the rate of NTDs in the 1xDTG group, although this did not reach statistical significance (p = 0.15, by Fisher's exact) ( Fig. 4 a).

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