Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.

We observed a strong trend toward a more advanced disease at diagnosis among patients with detectable CH by MSKCC-IMPACT ( Cerami et al., 2012 ; Gao et al., 2013 ; Fig. 1 A , P = 0.056, one-sided Fisher’s exact test comparing patients with local [stages 0, 1, and 2] and advanced [stages 3 and 4] disease, and Table 1 ).

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