Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice.

Pooled data from TRPC3 KO mice and controls revealed highly significant differences between the two groups at two distinct phases: (a) the early phase of the vasoconstriction and (b) hyperemia after the initial vasoconstriction.

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The peak of hyperemia showed a trend of increase in TRPC3KO mice ( Figure 4 b).

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