Effectiveness and Safety of Tranexamic Acid Use in Acute Traumatic Injury in the Prehospital and In-hospital Settings: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

24 However, the difference in thromboembolic events approached significance with increasing TXA dosage (placebo: 12.0%; 2 g: 26.5%; 4 g: 32.0%; P = 0.05). 24 Systematic Review of In-Hospital Use of TXA in TBI The CRASH-3 study examined the effect of TXA on TBI death in 9,127 patients randomly assigned to receive treatment or placebo within 3 hours of injury.

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