Interactions of EGFR/PTEN/mTOR-Pathway Activation and Estrogen Receptor Expression in Cervical Cancer.

A subgroup analysis of only FIGO II-IV tumor tissue samples with available adjacent negative tissue controls (n = 26) also demonstrated lower p-mTOR ( p = 0.048) and ER ( p < 0.001) expression levels in tumor samples; differences did not reach statistical significance for EGFR ( p = 0.087), PTEN ( p = 0.737) and PR ( p = 0.102). 3.3. p-mTOR Expression Correlates with EGFR Expression, ER Expression, and PTEN-Loss in Tumor Samples but Not in Matched Negative Controls In the overall cohort (n = 125), EGFR expression demonstrates a positive correlation with PTEN expression (r = 0.232, p = 0.015) and a negative correlation with p-mTOR expression (r = −0.309, p < 0.001).

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