Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology.

The correlation coefficient between both variables was 0.755 lower than that previously found for the intra-axonal T 2 in Figure 5 , and the p -value of the slope and the correlation did not reach statistical significance, p = 0.25.

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While this effect may be significant for short TEs, our relatively long TEs (i.e., > 73 ms) and diffusion times (Δ = 22 ms, δ = 8 ms) used in this study (compared to the small intra-axonal space where the restricted diffusion process takes place) indicate that a mono-exponential signal relaxation is expected for the spins inside each axon.

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