Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures.

Gene Ther · 2023 · PMC10457185 · PMID 37029201

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closest p · 1.4× alpha

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showed a trendP = 0.07so close (0.05 < p ≤ 0.1)

There was no statistically significant difference between the other groups, although AAV1-Y2/NPY showed a trend towards spending less time in motor seizure (AAV1-Y2/NPY, 20.2 ± 5.3 min, n = 8, P = 0.07).

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