Western blot analysis showed a trend towards reduction in the expression of tight junction proteins ZO-1 (Fig. 5 A) and occludin (Fig. 5 B) in the brain of C3GnT −/− as compared to the C3GnT +/+ mice, although quantification was not statistically significant at the protein level.
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Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice.
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