Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context.

PLoS Genet · 2023 · PMC10461826 · PMID 37585442

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nominally significantno p-value reported

Our ostensible ‘true negatives’ may well have exhibited shared genetic architecture within the MHC but not to an extent, within or without the MHC, sufficient to induce a nominally significant genetic correlation.

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highly significantno p-value reported

We performed tests with and without the inclusion of the major histocompatibility complex (MHC), a gene-rich locus which frequently exhibits highly significant association signals in GWAS of immune diseases [ 51 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.