Preclinical proof of concept of a tetravalent lentiviral T-cell vaccine against dengue viruses.

Our results demonstrate that immunization with an LV encoding the DEN T-cell poly-antigen including immunogenic regions of NS3, NS5, NS4B, and NS4A, induces highly significant protective effects against challenge with each of the four DENV serotypes in the preclinical murine model.

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Viral loads in the liver and small intestine were also lower in the LV IND -DEN-immunized mice, even if the differences did not reach statistical significance ( Figure 6F ).

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