Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis.

In ES-BIFAP, not only percentages increased but also the ITS analyses showed a significant trend increase after the 2018 RMMs in both the percentage of retinoids initiated within a recorded contraception episode (trend change =0.34%, p = 0.04) ( Figure 3 ) and contraceptives initiated 90 days prior to the start of a retinoid ( Supplementary Figure S3 ).

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