Anamnestic humoral correlates of immunity across SARS-CoV-2 variants of concern.

All FcγR-binding antibodies profiled (FcγRIIA, FcγRIIB, FcγRIIIA, and FcγRIIIB) were significantly expanded in Omicron VOC breakthrough infections for the full-length, trimeric spike similar to Delta breakthrough infections; the sole exception was FcγRIIIB for Delta VOC breakthrough cases, which trended strongly toward expansion but did not reach statistical significance ( Fig. 2A ).

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Comparison of SARS-CoV-2 RNA decay slopes with S2-peptide-specific IgG expansions for the first 3 weeks of breakthrough infection pointed to a highly significant inverse correlation between the slope of the evolution of FP-specific responses and viral clearance but only at the 2- to 3-week post-breakthrough timepoint ( Fig.

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