Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

Notably, the difference in the EC50 values of both TNBC cell lines, when compared to EC50 values of MCF-10 cells, was highly significant (p < 0.0001).

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Further supplementation with CP-8 only marginally increased the radiosensitivity of MDA-MB-231 cells (∼87% reduction in AUC) compared to untreated PRDX1 WT cells, and the magnitude of this increase did not reach statistical significance ( Fig. 4 E).

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