Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells.

In unvaccinated animals challenged with SCV2, the total lung CD3 + population was reduced at D4 and D7 to 4–6%; while BCG vaccinated, SCV2 challenged animals showed a trend to have nearly twice as many CD3 + cells (10–12%) at these same time points ( Figure 2 A) supporting our histopathological observations.

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