Our immunoblot data show that although there is a dose-dependent reduction of ppERK in BxPC-3 and H522, control cell lines for PDAC and NSCLC, respectively, ppERK level was initially elevated at 10 μM and showed a trend of decrease at higher concentrations in K-Ras-dependent cell lines ( Fig 1F ).
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A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95.
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