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The burden of ischemic heart disease and the epidemiologic transition in the Eastern Mediterranean Region: 1990-2019.

PLoS One · 2023 · PMC10479892 · PMID 37669274

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an unfavorable trendno p-value reported
On the other hand, Pakistan showed an unfavorable trend in death rates and DALYs, indicating the need for a comprehensive evaluation of their IHD treatment strategies.

also in 104 other papers

an increasing trendno p-value reported
Our findings indicate an increasing trend in the prevalence of IHD and a decrease in mortality and DALYs in the EMR.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.