“an unfavorable trend”

This mutation exhibited an unfavorable trend in terms of survival (HR 7.775; P < 0.001), indicating a potentially detrimental effect on patient outcomes [ 190 ].

The administration of adjuvant chemotherapy was associated with worse PFS ( p = 0.013), and an unfavorable trend was also observed for DM incidence ( p = 0.055).

By contrast, an unfavorable trend was observed in most developed countries and in older populations[ 14 ].

On the other hand, Pakistan showed an unfavorable trend in death rates and DALYs, indicating the need for a comprehensive evaluation of their IHD treatment strategies.

In Brazil, data from the Food and Nutrition Surveillance System (SISVAN in Portuguese) indicate an unfavorable trend toward obesity in Brazilian children between 5 and 10 years old, with a prevalence of 10.45% and 16.96% in a temporal variation between 2008 and 2021, respectively ( 3 ).

Czech healthcare is facing an unfavorable trend regarding the aging of nurses and their overall shortage in healthcare practice [ 26 ].

A stratified Cox model yielded a HR of 1.60 (95% CI: 0.78, 3.27) in Arm A and 1.53 (95% CI: 0.75, 3.15) in Arm B compared to SOC, indicating an unfavorable trend for the abemaciclib arms. 3.4 Safety Treatment‐emergent adverse events (TEAEs) occurred in >99% of the treated patients ( n = 98).

The incidence of PCa in China is steadily increasing, and over the past 30 years, the disease burden caused by PCa has further escalated, indicating an unfavorable trend ( 2 ).

The impact of LDHA expression level was not statistically significant ( p = 0.16), but an unfavorable trend can be observed. 3.2.

However, we observed an unfavorable trend of decreasing lymphadenectomy quality over the years.

An unfavorable trend occurred in three patients before the end of the first trimester of life due to multi-organ failure.

Furthermore, an unfavorable trend toward an earlier age at diagnosis has been noted, with a shift toward early childhood years [ 3 , 4 ].

We found that patients who showed an unfavorable trend of mutation abundances of KRAS, TP53, and/or CDKN2A at the second or third measurement mostly experienced PD within 4 months of chemotherapy.

Regarding βB application, an unfavorable trend was observed in the more severe KD subgroups (Figure 2 ).

Saudi Arabia is a rich country in EMR, in which the incidence rate was much higher than that of Pakistan, and it also showed an unfavorable trend.

In the univariate analysis in the chemoimmunotherapy cohort, CD8-high ( P = 0.0060) showed a significant association with PFS, while ECOG-PS ≥ 1 ( P = 0.0014) and SCLC-P (vs SCLC-I) ( P = 0.037) had an unfavorable association, and clinical stage (C-Stage ≥ IVB) ( P = 0.070) and SCLC-N (vs SCLC-I) ( P = 0.068) showed an unfavorable trend with PFS (Table 2 ).

However, in recent years, an unfavorable trend has been outlined, with hepatitis A continuing to occur in hyperendemic regions and emerging in areas of low endemicity [ 7 ].

Notably, both Complex 1 and Complex 6 exhibit favorable outcomes in terms of Coulombic interactions, whereas Complex 3 demonstrates an unfavorable trend in this regard.

Conclusions To sum up, the results of our study indicate a growing trend for the use of testosterone and anabolic–androgenic steroids and an increasing trend for gaining knowledge about these substances and their possible side effects, which unfortunately goes hand in hand with an unfavorable trend towards self-diagnosis and self-treatment of these effects.

However, the period effect for males shows an unfavorable trend over the period 2005-2014.

The reduced Young’s Modulus may indicate a ,,pseudo-plastic effect” for ceramic-polymer cements, while the compressive strength after modification showed an unfavorable trend.

Furthermore, an unfavorable trend has been observed in terms of the age at diagnosis, showing a shift toward early childhood years [ 3 – 5 ].

Furthermore, the recent period and cohort effects also indicate an unfavorable trend, which sounds an alarm for Nepal and indicates that more effort is needed to effectively control the increase in stroke-attributed mortality.

In addition, there was an unfavorable trend in the period effect of hypertensive heart disease due to cold temperatures in North America.

In contrast, the prevalence of DD in middle-SDI regions showed an unfavorable trend, with local drifts for all age groups indicating a downward trend and decreasing risk over time and across birth cohorts.