Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A.

Nat Commun · 2023 · PMC10480445 · PMID 37669939

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a clear trendno p-value reported

For example, after grouping β-cells from each donor into quartiles based on their T2D pseudo indexes, downregulated T2D marker genes S 100A10 , FXYD2 , and PPP1R1A and upregulated T2D marker genes CDKN2A , PDE4B , and SIX3 all demonstrated a clear trend of heterogeneity within the same donor (Fig. 4f, h ), in both healthy and T2D donors.

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