The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation.

Inflammatory skin diseases affect many people, and their incidence has shown an increasing trend year-over-year ( 12 – 14 ). moDCs are commonly used as a model to investigate prototypical cDC functions ( 15 – 18 ), and they can be readily found in any tissue during an inflammatory response ( 19 – 21 ).

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Neither TLR agonist was sufficient to elicit maturation of moDCs alone, as evidenced by the high percentage of DC-SIGN positive cells, and the fact that the increase in CD83 and CCR7 expression did not reach statistical significance ( Figures 3A–C ).

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