A clear trend for increased methylation levels was obtained in LRF-OE+hemin/EPO cell clones lengthwise every CpG island sequence, whereas cell subgroups of UT, UT+hemin/EPO, and LRF-OE displayed insignificant levels of 5′ methyl-cytosines over unmethylated cytosines in corresponding CpG islands (Fig. 2 B).
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Transcriptional repression of lncRNA and miRNA subsets mediated by LRF during erythropoiesis.
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