a marked trendp = 0.08
Smad3-infected cells in the Ad-Smad3 and Ad-Smad3/Ad-FoxO3 groups showed significant increases in phosphorylated and total Smad3 in the cytoplasm ( Figures 6C, D ), a marked trend ( p = 0.08) for increased phosphorylated Smad3 in the nucleus ( Figure 6E ), and significantly increased total Smad3 in the nucleus ( Figure 6F ) compared to Ad-GFP cells.