Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified?

BMC Gastroenterol · 2023 · PMC10483799 · PMID 37674110

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did not reach statistical significanceno p-value reported

In a meta-analysis containing 480 patients from 10 RCTs there was a minor effect of PPI compared to placebo (RR 1.31, 95%CI 1.03–1.67) and interestingly the preplanned analysis of the effects of PPI treatment without dietary and lifestyle modifications did not reach statistical significance [ 54 ].

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