Good Enough? Terlipressin, Hepatorenal Syndrome, and the Usage of RRT.

Two large, randomized phase III clinical trials, OT-0401 and REVERSE, demonstrated higher rates of HRS reversal, but the results did not reach statistical significance. 8 , 9 More recently, the CONFIRM trial randomized 300 patients 2:1 to terlipressin verses placebo (both groups also treated with albumin) and found a higher rate of verified HRS reversal, defined as two consecutive serum creatinine measurements <1.5 mg/dl up to day 14 and survival without RRT for

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