A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice.

Line effect The morphometric data on Ca.Th and %PoV indicated that the CC line had a highly significant effect, with p < 0.0001 for both traits (Table 1 ).

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In five lines out of 15 the bone density was higher in males, nine lines did not show any sex effect and one line showed a trend for a 2‐fold higher bone density in females. 19 Such a sexual dimorphism was also reported in the context of the genetic regulation of calvarial bone, as evidenced by the sex‐specific phenotype (increased cranial BMD) of Annexin1 ( AnxA1 ) knockout male mice. 37 5.

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