A Functional Genomics Review of Non-Small-Cell Lung Cancer in Never Smokers.

Int J Mol Sci · 2023 · PMC10488233 · PMID 37686122

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marginally significantno p-value reported

Moreover, co-occurring patterns were also found between RBM10 and PIK3CA , as well as between TP53 and ERBB2 and marginally significant enrichment of SETD2 mutations, in samples with oncogene fusions, particularly in TP53-proficient tumours.

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showed a trendno p-value reported

Mutations in PTEN or STK11 were significantly associated with a low ORR to EGFR-TKIs; mutations in PIK3CA and AKT did not differ significantly in terms of treatment response but showed a trend toward poor responses.

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