Preparation and Characterization of Spray-Dried Hybrid Nanocrystal-Amorphous Solid Dispersions (HyNASDs) for Supersaturation Enhancement of a Slowly Crystallizing Drug.

Nanomaterials (Basel) · 2023 · PMC10490532 · PMID 37686927

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a clear trendno p-value reported

Therefore, there is a clear trend: an increase in Sol loading led to a higher amorphous content, higher micellar solubilization, and eventually higher ITZ supersaturation, while the precursor ITZ nanoparticle suspensions used to prepare these spray-dried powders did not have drastically different ITZ particle sizes.

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