Enhanced therapeutic effect of PEDF-loaded mesenchymal stem cell-derived small extracellular vesicles against oxygen-induced retinopathy through increased stability and penetrability of PEDF.

J Nanobiotechnology · 2023 · PMC10492320 · PMID 37684667

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showed a trendno p-value reported

In contrast, anti-VEGF drugs showed a trend towards deterioration.

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highly significantno p-value reported

These effects were successfully reduced by PEDF-sEV treatment, and the difference was highly significant compared to the PEDF, sEVs, and mixture groups (Fig. 2 H, I).

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