Barely Significant
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The early-phase transcriptome and the clinical efficacy analysis in three modes of subcutaneous immunotherapy for allergic rhinitis.

World Allergy Organ J · 2023 · PMC10493265 · PMID 37701629

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a decreasing trendno p-value reported
Although other cytokines, such as IL-4 and IL-17, showed a decreasing trend, they did not reach statistical significance due to the small sample size and substantial variability within the data groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.