Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in <i>B. vulgatus</i> and serotonin metabolism in hippocampus.

It was found that the number of Bacteroides in the feces of morphine induced CPP model mice decreased and showed a trend of recovery after drug discontinuation; 27 the number of Bacteroides in the feces of patients using opioid agonists decreased. 28 B. vulgatus , the dominant species of the mouse intestinal Bacteroides , had reduced abundance in the feces of morphine-exposed mice. 20 In this study, we found that oral administration of miR-129-5p decreased the relative abundance of B. vulgatus in the feces and increased the levels of 5-HT in the hippocampus.

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