Contrary to the above situation, IU1 stimulation decreased the total amount of the 26S proteasomes while showing an increasing trend for the 20S free CP ( Figure 5B ).
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Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux.
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Furthermore, we noticed that IU1 could reduce the amount of USP14 containing 26S proteasome complexes although the extent of decrease did not reach statistical significance ( Figure 5B , lower blots).