Dysregulation of core neurodevelopmental pathways-a common feature of cancers with perineural invasion.

For SEMA3A , SEMA3C, and SEMA7A as well as the semaphorin receptor neuropilin, there was a clear trend where the expression above the cutoff was associated with worse survival for all three cancers ( Figures 6 , 7C ; Supplementary Table 12 ).

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Expression above the cutoff of WNT3 showed a marginal trend toward overall better survival; however, this was not significant.

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Similarly, even when highly significant, the degree of dysregulation between samples from different individuals for a particular gene varied considerably (e.g., see Supplementary Figure S18 ).

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