Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.

Although nominally significant differences (Welch’s 1-sided t-test, alpha=0.05) in mean breadth of response between cases and pediatric controls were detected across 5 pathogens ( Fig. 1B ), only differences in responses to 4 Parvoviridae species (Adeno-associated dependoparvovirus A, Adeno-associated virus, Adeno-associated virus VR-355, and non-human primate Adeno-associated virus) were significant after correcting for multiple hypothesis testing [false discovery rate (FDR) = 0.05].

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